Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation
نویسندگان
چکیده
منابع مشابه
Accumulation of anandamide: evidence for cellular diversity.
The endocannabinoid N-arachidonylethanolamine (AEA) is accumulated by many cell types, but the mechanisms are unknown. Data from several laboratories are consistent with the hypothesis that the accumulation of AEA occurs via the action of a transmembrane carrier that binds and transports AEA. However, other data suggest that AEA is sufficiently lipophilic to transverse plasma membranes by passi...
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Role of FAAH-Like Anandamide Transporter in Anandamide Inactivation
The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase (FAAH). Recently, FAAH-like anandamide transporter (FLAT), a truncated and catalytically-inactive variant of FAAH, was proposed to function as...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2008
ISSN: 0022-2275
DOI: 10.1194/jlr.m700486-jlr200